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Distinct cellular responses to replication stress leading to apoptosis or senescence
Replication stress (RS) is a major driver of genomic instability and tumorigenesis. Here, we investigated whether RS induced by the nucleotide analog fludarabine and specific kinase inhibitors [e.g. targeting checkpoint kinase 1 (Chk1) or ataxia telangiectasia and Rad3‐related (ATR)] led to apoptosi...
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| Publicado no: | FEBS Open Bio |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6487726/ https://ncbi.nlm.nih.gov/pubmed/30982228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12632 |
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