Human aldehyde oxidase (hAOX1): structure determination of the Moco‐free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms

Human aldehyde oxidase (hAOX1) is a molybdenum enzyme with high toxicological importance, but its physiological role is still unknown. hAOX1 metabolizes different classes of xenobiotics and is one of the main drug‐metabolizing enzymes in the liver, along with cytochrome P450. hAOX1 oxidizes and inac...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FEBS Open Bio
Main Authors: Mota, Cristiano, Esmaeeli, Mariam, Coelho, Catarina, Santos‐Silva, Teresa, Wolff, Martin, Foti, Alessandro, Leimkühler, Silke, Romão, Maria João
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487702/
https://ncbi.nlm.nih.gov/pubmed/30985987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12617
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