Suppression of Th1 priming by TLR2 agonists during cutaneous immunization is mediated by recruited CCR2(+) monocytes.

Effective subunit vaccines require the incorporation of adjuvants that stimulate cells of the innate immune system to generate protective adaptive immune responses. Pattern recognition receptor (PRR) agonists are a growing class of potential adjuvants that can shape the character of the immune respo...

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Veröffentlicht in:J Immunol
Hauptverfasser: Johndrow, Christopher T., Goldberg, Michael F., Johnson, Alison J., Ng, Tony W., Kunnath-Velayudhan, Shajo, Lauvau, Gregoire, Gossel, Graeme H., Kadolsky, Ulrich D, Yates, Andrew J., Chan, John, Jacobs, William R., Porcelli, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487659/
https://ncbi.nlm.nih.gov/pubmed/30455402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801185
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