Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Cancer treatment by immune checkpoint blockade (ICB) can bring long-lasting clinical benefits, but only a fraction of patients respond to treatment. To predict ICB response, we developed TIDE, a computational method to model two primary mechanisms of tumor immune evasion: the induction of T cell dys...

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Udgivet i:Nat Med
Main Authors: Jiang, Peng, Gu, Shengqing, Pan, Deng, Fu, Jingxin, Sahu, Avinash, Hu, Xihao, Li, Ziyi, Traugh, Nicole, Bu, Xia, Li, Bo, Liu, Jun, Freeman, Gordon J., Brown, Myles A., Wucherpfennig, Kai W., Liu, X. Shirley
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487502/
https://ncbi.nlm.nih.gov/pubmed/30127393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0136-1
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