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Mapping the Azolog Space Enables the Optical Control of New Biological Targets

[Image: see text] Photopharmacology relies on molecules that change their biological activity upon irradiation. Many of these are derived from known drugs by replacing their core with an isosteric azobenzene photoswitch (azologization). The question is how many of the known bioactive ligands could b...

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Bibliografiska uppgifter
I publikationen:ACS Cent Sci
Huvudupphovsmän: Morstein, Johannes, Awale, Mahendra, Reymond, Jean-Louis, Trauner, Dirk
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2019
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487453/
https://ncbi.nlm.nih.gov/pubmed/31041380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00881
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