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Mapping the Azolog Space Enables the Optical Control of New Biological Targets

[Image: see text] Photopharmacology relies on molecules that change their biological activity upon irradiation. Many of these are derived from known drugs by replacing their core with an isosteric azobenzene photoswitch (azologization). The question is how many of the known bioactive ligands could b...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Morstein, Johannes, Awale, Mahendra, Reymond, Jean-Louis, Trauner, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487453/
https://ncbi.nlm.nih.gov/pubmed/31041380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00881
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