Inhibition of Fascin in Cancer and Stromal Cells Blocks Ovarian Cancer Metastasis

OBJECTIVE: Ovarian cancer (OvCa) metastasis requires the coordinated motility of both cancer and stromal cells. Cellular movement is a dynamic process that involves the synchronized assembly of f-actin bundles into cytoskeletal protrusions by fascin. Fascin directly binds factin and is an integral c...

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Foilsithe in:Gynecol Oncol
Main Authors: McGuire, Sean, Kara, Betul, Hart, Peter C., Montag, Anthony, Wroblewski, Kristen, Fazal, Sarah, Huang, Xin-Yun, Lengyel, Ernst, Kenny, Hilary A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486884/
https://ncbi.nlm.nih.gov/pubmed/30797592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2019.01.020
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