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Fibroblasts in Pancreatic Ductal Adenocarcinoma: biological mechanisms and therapeutic targets

The desmoplastic reaction of pancreas cancer may begin as a wound healing response to the nascent neoplasm, but it soon creates an insidious shelter that can sustain the growing tumor and rebuff therapy. Among the many cell types subverted by transformed epithelial cells, fibroblasts are recruited a...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Whittle, Martin C., Hingorani, Sunil R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486863/
https://ncbi.nlm.nih.gov/pubmed/30721663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.12.044
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