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NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Diabetes increases the risk and worsens the progression of cognitive impairment via the greater occurrence of small vessel disease and stroke. Yet, the underlying mechanisms are not fully understood. It is now accepted that cardiovascular health is critical for brain health and any neurorestorative...

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Detalhes bibliográficos
Publicado no:Pharmacol Res
Main Authors: Ward, Rebecca, Li, Weiguo, Abdul, Yasir, Jackson, LaDonya, Dong, Guangkuo, Jamil, Sarah, Filosa, Jessica, Fagan, Susan C., Ergul, Adviye
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486792/
https://ncbi.nlm.nih.gov/pubmed/30818045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phrs.2019.01.035
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