Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound

DNA-reactive compounds are harnessed for cancer chemotherapy. Their genotoxic effects are considered to be the main mechanism for the cytotoxicity to date. Because this mechanism preferentially affects actively proliferating cells, it is postulated that the cytotoxicity is specific to cancer cells....

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Kunkeaw, Nawapol, Lee, Yeon-Su, Im, Wonkyun Ronny, Jang, Jiyoung Joan, Song, Min-Ji, Yang, Bobae, Park, Jong-Lyul, Kim, Seon-Young, Ku, Yongsuk, Kim, Yoosik, Kang, Sangmin, Jo, Hye-ram, Jeong, Jae-Hoon, Lee, Hyun-Sung, Lee, Ju-Seog, Kim, Hyoung-Pyo, Johnson, Betty H., Kim, In-Hoo, Lee, Yong Sun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486756/
https://ncbi.nlm.nih.gov/pubmed/30948645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814510116
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