Mechanism mediated by a noncoding RNA, nc886, in the cytotoxicity of a DNA-reactive compound

DNA-reactive compounds are harnessed for cancer chemotherapy. Their genotoxic effects are considered to be the main mechanism for the cytotoxicity to date. Because this mechanism preferentially affects actively proliferating cells, it is postulated that the cytotoxicity is specific to cancer cells....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kunkeaw, Nawapol, Lee, Yeon-Su, Im, Wonkyun Ronny, Jang, Jiyoung Joan, Song, Min-Ji, Yang, Bobae, Park, Jong-Lyul, Kim, Seon-Young, Ku, Yongsuk, Kim, Yoosik, Kang, Sangmin, Jo, Hye-ram, Jeong, Jae-Hoon, Lee, Hyun-Sung, Lee, Ju-Seog, Kim, Hyoung-Pyo, Johnson, Betty H., Kim, In-Hoo, Lee, Yong Sun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486756/
https://ncbi.nlm.nih.gov/pubmed/30948645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814510116
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