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Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

The PIK3CA gene, which encodes the p110α catalytic subunit of PI3 kinase (PI3K), is mutationally activated in cancer and in overgrowth disorders known as PIK3CA-related overgrowth spectrum (PROS). To determine the consequences of genetic PIK3CA activation in a developmental context of relevance to b...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Madsen, Ralitsa R., Knox, Rachel G., Pearce, Wayne, Lopez, Saioa, Mahler-Araujo, Betania, McGranahan, Nicholas, Vanhaesebroeck, Bart, Semple, Robert K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486754/
https://ncbi.nlm.nih.gov/pubmed/30948643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821093116
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