Simultaneous determination of intracellular concentrations of tenofovir, emtricitabine, and dolutegravir in human brain microvascular endothelial cells using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Combination antiretroviral therapy (cART) regimens are recommended for HIV patients to better achieve and maintain plasma viral suppression. Despite adequate plasma viral suppression, HIV persists inside the brain, which is, in part thought to result from poor brain penetration of antiretroviral dru...

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Veröffentlicht in:Anal Chim Acta
Hauptverfasser: Patel, Sulay H., Ismaiel, Omnia A., Mylott, William R, Yuan, Moucun, Hauser, Kurt F., McRae, MaryPeace
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486649/
https://ncbi.nlm.nih.gov/pubmed/30797464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2019.01.015
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