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Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment

While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood. Here, we tissue-engineered and validated an in vitro microtissue model of osteoblastic bone metastases, and us...

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Detalhes bibliográficos
Publicado no:Bone Res
Principais autores: Bock, Nathalie, Shokoohmand, Ali, Kryza, Thomas, Röhl, Joan, Meijer, Jonelle, Tran, Phong A., Nelson, Colleen C., Clements, Judith A., Hutmacher, Dietmar W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486620/
https://ncbi.nlm.nih.gov/pubmed/31044095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-019-0049-8
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