LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex

In PTEN-deficient prostate cancers, AKT signaling may be activated upon suppression of androgen receptor signaling. Activation of AKT as well as NF-κB signaling involves a key regulatory protein complex containing PHLPP, FKBP51 and IKKα. Here, we report a critical role of lncRNA PCAT1 in regulating...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Shang, Zhiqun, Yu, Jianpeng, Sun, Libin, Tian, Jing, Zhu, Shimiao, Zhang, Boya, Dong, Qian, Jiang, Ning, Flores-Morales, Amilcar, Chang, Chawnshang, Niu, Yuanjie
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486551/
https://ncbi.nlm.nih.gov/pubmed/30773595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz108
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