Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8(+) T Cells and Evolve at the Population Level

BACKGROUND & AIMS: Hepatitis D virus (HDV) superinfection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8(+) T cells are thought to...

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Udgivet i:Gastroenterology
Main Authors: Karimzadeh, Hadi, Kiraithe, Muthamia M., Oberhardt, Valerie, Salimi Alizei, Elahe, Bockmann, Jan, Schulze zur Wiesch, Julian, Budeus, Bettina, Hoffmann, Daniel, Wedemeyer, Heiner, Cornberg, Markus, Krawczyk, Adalbert, Rashidi-Alavijeh, Jassin, Rodríguez-Frías, Francisco, Casillas, Rosario, Buti, Maria, Smedile, Antonina, Alavian, Seyed Moayed, Heinold, Andreas, Emmerich, Florian, Panning, Marcus, Gostick, Emma, Price, David A., Timm, Jörg, Hofmann, Maike, Raziorrouh, Bijan, Thimme, Robert, Protzer, Ulrike, Roggendorf, Michael, Neumann-Haefelin, Christoph
Format: Artigo
Sprog:Inglês
Udgivet: W.B. Saunders 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486497/
https://ncbi.nlm.nih.gov/pubmed/30768983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.02.003
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