Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8(+) T Cells

Virus-specific CD8 T cell response seems to play a significant role in the outcome of hepatitis delta virus (HDV) infection. However, the HDV-specific T cell epitope repertoire and mechanisms of CD8 T cell failure in HDV infection have been poorly characterized. We therefore aimed to characterize HD...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Karimzadeh, Hadi, Kiraithe, Muthamia M., Kosinska, Anna D., Glaser, Manuel, Fiedler, Melanie, Oberhardt, Valerie, Salimi Alizei, Elahe, Hofmann, Maike, Mok, Juk Yee, Nguyen, Melanie, van Esch, Wim J. E., Budeus, Bettina, Grabowski, Jan, Homs, Maria, Olivero, Antonella, Keyvani, Hossein, Rodríguez-Frías, Francisco, Tabernero, David, Buti, Maria, Heinold, Andreas, Alavian, Seyed Moayed, Bauer, Tanja, Schulze zur Wiesch, Julian, Raziorrouh, Bijan, Hoffmann, Daniel, Smedile, Antonina, Rizzetto, Mario, Wedemeyer, Heiner, Timm, Jörg, Antes, Iris, Neumann-Haefelin, Christoph, Protzer, Ulrike, Roggendorf, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002722/
https://ncbi.nlm.nih.gov/pubmed/29669837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01891-17
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