miR-142 controls metabolic reprogramming that regulates dendritic cell activation

DCs undergo metabolic reprogramming from a predominantly oxidative phosphorylation (OXPHOS) to glycolysis to mount an immunogenic response. The mechanism underpinning the metabolic reprogramming remains elusive. We demonstrate that miRNA-142 (miR-142) is pivotal for this shift in metabolism, which r...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Sun, Yaping, Oravecz-Wilson, Katherine, Bridges, Sydney, McEachin, Richard, Wu, Julia, Kim, Stephanie H., Taylor, Austin, Zajac, Cynthia, Fujiwara, Hideaki, Peltier, Daniel Christopher, Saunders, Thomas, Reddy, Pavan
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486330/
https://ncbi.nlm.nih.gov/pubmed/30958798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI123839
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