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Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8(+) T cells
Recent studies have highlighted a central role for intestinal dendritic cells (DCs) and vitamin A metabolite retinoic acid (RA) in the generation of α4β7(+) CCR9(+) “gut tropic” effector T cells. Here, using RA-responsive element reporter mice, we demonstrate that both splenic and mesenteric lymph n...
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| Udgivet i: | Mucosal Immunol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6485487/ https://ncbi.nlm.nih.gov/pubmed/19079159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2007.4 |
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