Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma

Medulloblastoma (MB) is the most prevalent malignant brain tumor in children, accounting for 20% of all childhood brain tumors. The molecular profiling of MB into 4 major subgroups (WNT, SHH, Grp3, and Grp4) emphasizes the heterogeneity of MB and opens paths in which treatments may be targeted to mo...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Veo, Bethany, Danis, Etienne, Pierce, Angela, Sola, Ismail, Wang, Dong, Foreman, Nicholas K., Jin, Jian, Ma, Anqi, Serkova, Natalie, Venkataraman, Sujatha, Vibhakar, Rajeev
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485357/
https://ncbi.nlm.nih.gov/pubmed/30626740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122933
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