Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome

BACKGROUND AND PURPOSE—: A major process contributing to cell death in the ischemic brain is inflammation. Inflammasomes are multimolecular protein complexes that drive inflammation through activation of proinflammatory cytokines, such as IL (interleukin)-1β. Preclinical evidence suggests that IL-1β...

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Bibliographic Details
Published in:Stroke
Main Authors: Lemarchand, Eloise, Barrington, Jack, Chenery, Alistair, Haley, Michael, Coutts, Graham, Allen, Judith E., Allan, Stuart M., Brough, David
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6485300/
https://ncbi.nlm.nih.gov/pubmed/31009361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/STROKEAHA.118.023620
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