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Perturbations in the impact of mutational activity on Vλ genes in systemic lupus erythematosus

To assess the impact of somatic hypermutation and selective influences on the Vλ light chain repertoire in systemic lupus erythematosus (SLE), the frequency and pattern of mutations were analyzed in individual CD19(+) B cells from a patient with previously undiagnosed SLE. The mutational frequency o...

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Autors principals: Dörner, Thomas, Kaschner, Sabine, Hansen, Arne, Pruss, Axel, Lipsky, Peter E
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC64848/
https://ncbi.nlm.nih.gov/pubmed/11714391
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