Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation

AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk. However, whether this is mediated by cell-autonomous AMPK...

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Udgivet i:Cell Rep
Main Authors: Vara-Ciruelos, Diana, Dandapani, Madhumita, Russell, Fiona M., Grzes, Katarzyna M., Atrih, Abdelmadjid, Foretz, Marc, Viollet, Benoit, Lamont, Douglas J., Cantrell, Doreen A., Hardie, D. Grahame
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484776/
https://ncbi.nlm.nih.gov/pubmed/30995468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.03.067
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