Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma

Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated RAS/RAF/MEK/ERK signaling. In this study, we report the identification of a novel recurrent BRAF insertion (p.V504_R506dup) in five PA cases harboring exclusively this somatic tandem duplication. This recurrent alteration lea...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Khater, Fida, Langlois, Sylvie, Cassart, Pauline, Roy, Anne-Marie, Lajoie, Mathieu, Healy, Jasmine, Richer, Chantal, St-Onge, Pascal, Piché, Nelson, Perreault, Sebastien, Cellot, Sonia, Marzouki, Monia, Jabado, Nada, Sinnett, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484687/
https://ncbi.nlm.nih.gov/pubmed/30575814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0623-3
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