The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells

Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T-cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) have not been identified. We report multivariable analyses of factors affecting response and progression-free survival (PFS) in patients...

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Udgivet i:Blood
Main Authors: Hirayama, Alexandre V., Gauthier, Jordan, Hay, Kevin A., Voutsinas, Jenna M., Wu, Qian, Gooley, Ted, Li, Daniel, Cherian, Sindhu, Chen, Xueyan, Pender, Barbara S., Hawkins, Reed M., Vakil, Aesha, Steinmetz, Rachel N., Acharya, Utkarsh H., Cassaday, Ryan D., Chapuis, Aude G., Dhawale, Tejaswini M., Hendrie, Paul C., Kiem, Hans-Peter, Lynch, Ryan C., Ramos, Jorge, Shadman, Mazyar, Till, Brian G., Riddell, Stanley R., Maloney, David G., Turtle, Cameron J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484391/
https://ncbi.nlm.nih.gov/pubmed/30782611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-11-887067
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