Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity

Iron deficiency is present in ~50% of heart failure (HF) patients. Large multicenter trials have shown that treatment of iron deficiency with i.v. iron benefits HF patients, but the underlying mechanisms are not known. To investigate the actions of iron deficiency on the heart, mice were fed an iron...

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Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Chung, Yu Jin, Luo, Antao, Park, Kyung Chan, Loonat, Aminah A., Lakhal-Littleton, Samira, Robbins, Peter A., Swietach, Pawel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483648/
https://ncbi.nlm.nih.gov/pubmed/30779710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.125618
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