TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons

The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. We identified a potentially novel Ca(2+)-activated chloride (Cl(–)) current (CaCC) that is induced by CCK in intestinal vagal afferents of nodose neurons....

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Bibliographic Details
Published in:JCI Insight
Main Authors: Wang, Runping, Lu, Yongjun, Cicha, Michael Z., Singh, Madhu V., Benson, Christopher J., Madden, Christopher J., Chapleau, Mark W., Abboud, François M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483506/
https://ncbi.nlm.nih.gov/pubmed/30843875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122058
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