TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons

The satiety effects and metabolic actions of cholecystokinin (CCK) have been recognized as potential therapeutic targets in obesity for decades. We identified a potentially novel Ca(2+)-activated chloride (Cl(–)) current (CaCC) that is induced by CCK in intestinal vagal afferents of nodose neurons....

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Publicat a:JCI Insight
Autors principals: Wang, Runping, Lu, Yongjun, Cicha, Michael Z., Singh, Madhu V., Benson, Christopher J., Madden, Christopher J., Chapleau, Mark W., Abboud, François M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483506/
https://ncbi.nlm.nih.gov/pubmed/30843875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122058
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