p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

There are still gaps in our understanding of the complex processes by which p53 suppresses tumorigenesis. Here we describe a novel role for p53 in suppressing the mevalonate pathway, which is responsible for biosynthesis of cholesterol and nonsterol isoprenoids. p53 blocks activation of SREBP-2, the...

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Published in:Cell
Main Authors: Moon, Sung-Hwan, Huang, Chun-Hao, Houlihan, Shauna L., Regunath, Kausik, Freed-Pastor, William A., Morris, John P., Tschaharganeh, Darjus F., Kastenhuber, Edward R., Barsotti, Anthony M., Culp-Hill, Rachel, Xue, Wen, Ho, Yu-Jui, Baslan, Timour, Li, Xiang, Mayle, Allison, de Stanchina, Elisa, Zender, Lars, Tong, David R., D’Alessandro, Angelo, Lowe, Scott W., Prives, Carol
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483089/
https://ncbi.nlm.nih.gov/pubmed/30580964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.11.011
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