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Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease

In inflammatory diseases, the 5-lipoxygenase (5-LO) pathway contributes to epithelial damage and fibrosis by catalyzing the production of leukotrienes (LTs). Antagonists of the 5-LO pathway are currently approved for use in patients and are well tolerated. We found that expression of 5-LO is strongl...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Montford, John R., Bauer, Colin, Dobrinskikh, Evgenia, Hopp, Katharina, Levi, Moshe, Weiser-Evans, Mary, Nemenoff, Raphael, Furgeson, Seth B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483031/
https://ncbi.nlm.nih.gov/pubmed/30649890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00262.2018
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