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NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5

Insulin-like growth factor binding protein-5 (IGFBP-5) induces production of the extracellular matrix (ECM) components collagen and fibronectin both in vitro and in vivo and is overexpressed in patients with fibrosing lung diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Yasuoka, Hidekata, Garrett, Sara M., Nguyen, Xinh-Xinh, Artlett, Carol M., Feghali-Bostwick, Carol A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6483014/
https://ncbi.nlm.nih.gov/pubmed/30810066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00106.2018
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