Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis

B cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS). Clonally related B cells exist in the cerebrospinal fluid (CSF), meninges, and CNS parenchyma of MS patients. We sought to investigate the presence of clonally related B cells over time by performing Ig heavy ch...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Greenfield, Ariele L., Dandekar, Ravi, Ramesh, Akshaya, Eggers, Erica L., Wu, Hao, Laurent, Sarah, Harkin, William, Pierson, Natalie S., Weber, Martin S., Henry, Roland G., Bischof, Antje, Cree, Bruce A.C., Hauser, Stephen L., Wilson, Michael R., von Büdingen, H.-Christian
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482992/
https://ncbi.nlm.nih.gov/pubmed/30747723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126599
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