Longitudinally persistent cerebrospinal fluid B cells can resist treatment in multiple sclerosis

B cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS). Clonally related B cells exist in the cerebrospinal fluid (CSF), meninges, and CNS parenchyma of MS patients. We sought to investigate the presence of clonally related B cells over time by performing Ig heavy ch...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Greenfield, Ariele L., Dandekar, Ravi, Ramesh, Akshaya, Eggers, Erica L., Wu, Hao, Laurent, Sarah, Harkin, William, Pierson, Natalie S., Weber, Martin S., Henry, Roland G., Bischof, Antje, Cree, Bruce A.C., Hauser, Stephen L., Wilson, Michael R., von Büdingen, H.-Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482992/
https://ncbi.nlm.nih.gov/pubmed/30747723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126599
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