Preparation and evaluation of (99m)Tc-labeled porphyrin complexes prepared using PNP and HYNIC cores: studying the effects of core selection on pharmacokinetics and tumor uptake in a mouse model

Porphyrins are tetrapyrrolic macrocyclic ligands known for their affinity towards neoplastic tissues and once radiolabeled with a suitable diagnostic radioisotope could potentially be used for the imaging of tumorous lesions. In the present study, an unsymmetrically substituted porphyrin derivative...

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Vydáno v:Medchemcomm
Hlavní autoři: Guleria, Mohini, Das, Tapas, Vats, Kusum, Amirdhanayagam, Jeyachitra, Mathur, Anupam, Sarma, Haladhar D., Dash, Ashutosh
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482877/
https://ncbi.nlm.nih.gov/pubmed/31057740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00559a
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