Altered expression of p63 isoforms and expansion of p63- and club cell secretory protein-positive epithelial cells in the lung as novel features of aging

Aging is a key contributor for subclinical progression of late-onset lung diseases. Basal, club, and type II alveolar epithelial cells (AECs) are lung epithelial progenitors whose capacities of differentiation are extensively studied. The timely transition of these cells in response to environmental...

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Publicado en:Am J Physiol Cell Physiol
Autores principales: Fukumoto, Jutaro, Sidramagowda Patil, Sahebgowda, Krishnamurthy, Sudarshan, Saji, Smita, John, Irene, Narala, Venkata Ramireddy, Hernández-Cuervo, Helena, Alleyn, Matthew, Breitzig, Mason T., Galam, Lakshmi, Soundararajan, Ramani, Chaudhari, Uddhav K., Hansen, Barbara C., Lockey, Richard F., Kolliputi, Narasaiah
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482668/
https://ncbi.nlm.nih.gov/pubmed/30649915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00330.2018
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