Upregulation of miR-214 Induced Radioresistance of Osteosarcoma by Targeting PHLDA2 via PI3K/Akt Signaling

Osteosarcoma is an aggressive bone tumor with high resistance to radiotherapy. Pleckstrin homology-like domain family A member 2 (PHLDA2) displays low expression in human osteosarcoma as a proapoptosis factor. miRNAs have been shown to be important in modulating translation and therapeutic responsiv...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Li, Yi, Song, Xinmao, Liu, Zegang, Li, Qiutian, Huang, Meijin, Su, Bin, Mao, Yuchi, Wang, Yuanyuan, Mo, Wenqian, Chen, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482205/
https://ncbi.nlm.nih.gov/pubmed/31058093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00298
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