BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival

Malignant melanoma is one of the most difficult cancers to treat due to its resistance to chemotherapy. Despite recent successes with BRAF inhibitors and immune checkpoint inhibitors, many patients do not respond or become resistant to these drugs. Hence, alternative treatments are still required. D...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Lee, Erinna F., Harris, Tiffany J., Tran, Sharon, Evangelista, Marco, Arulananda, Surein, John, Thomas, Ramnac, Celeste, Hobbs, Chloe, Zhu, Haoran, Gunasingh, Gency, Segal, David, Behren, Andreas, Cebon, Jonathan, Dobrovic, Alexander, Mariadason, John M., Strasser, Andreas, Rohrbeck, Leona, Haass, Nikolas K., Herold, Marco J., Fairlie, W. Douglas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482196/
https://ncbi.nlm.nih.gov/pubmed/31019203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1568-3
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