Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine

Previous data from our laboratory show that expression of the P2X7 receptor (P2X7R) is needed for amyloid β (Aβ)-stimulated microglia activation and IL-1β release in vitro and in vivo. We also showed that Aβ-dependent stimulation is inhibited by the dihydropyridine nimodipine at an intracellular sit...

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Published in:Sci Rep
Main Authors: Chiozzi, Paola, Sarti, Alba Clara, Sanz, Juana M., Giuliani, Anna Lisa, Adinolfi, Elena, Vultaggio-Poma, Valentina, Falzoni, Simonetta, Di Virgilio, Francesco
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482182/
https://ncbi.nlm.nih.gov/pubmed/31019207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42931-2
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