Mutant huntingtin enhances activation of dendritic Kv4 K(+) channels in striatal spiny projection neurons

Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mechanisms underlying this deficit, striatal neurons in...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Carrillo-Reid, Luis, Day, Michelle, Xie, Zhong, Melendez, Alexandria E, Kondapalli, Jyothisri, Plotkin, Joshua L, Wokosin, David L, Chen, Yu, Kress, Geraldine J, Kaplitt, Michael, Ilijic, Ema, Guzman, Jaime N, Chan, C Savio, Surmeier, D James
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481990/
https://ncbi.nlm.nih.gov/pubmed/31017573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.40818
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