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Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice
Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase, desipramine, improved vascular dysfunction in db/db mice. High gluco...
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| Publicado no: | Biosci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6481240/ https://ncbi.nlm.nih.gov/pubmed/30910852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20182144 |
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