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Inhibition of acid sphingomyelinase activity ameliorates endothelial dysfunction in db/db mice
Acid sphingomyelinase (aSMase) plays an important role in endothelial dysfunction. Here, we show that elevated aSMase activity and ceramide content were reduced by desipramine treatment in diabetic animals. The inhibitor of aSMase, desipramine, improved vascular dysfunction in db/db mice. High gluco...
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| Pubblicato in: | Biosci Rep |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Portland Press Ltd.
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6481240/ https://ncbi.nlm.nih.gov/pubmed/30910852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20182144 |
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