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Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
Temozolomide (TMZ) is an alkylating agent used in the treatment of high-grade malignant glioma, notably glioblastoma multiforme, the most aggressive form of brain cancer. The drug induces a dozen DNA methylation adducts, including O(6)-methylguanine (O(6)MeG), which is the most toxic primary DNA les...
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| Published in: | Int J Mol Sci |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
MDPI
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6480213/ https://ncbi.nlm.nih.gov/pubmed/30925722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20071562 |
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