Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist

Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Memantine (MEM) is a non-competitive N-...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Zhang, Yunpeng, Li, Shuping, Wang, Youxu, Deng, Gang, Cao, Ning, Wu, Chao, Ding, Wenzheng, Wang, Yuwen, Cheng, Xuemei, Wang, Changhong
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479946/
https://ncbi.nlm.nih.gov/pubmed/30978991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24071430
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