Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

OBJECTIVE: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (Tim-3) has complicated roles in regulating ma...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Yang, Huimin, Xie, Tingting, Li, Dengren, Du, Xianhong, Wang, Tixiao, Li, Chunyang, Song, Xiaojia, Xu, Leiqi, Yi, Fan, Liang, Xiaohong, Gao, Lifen, Yang, Xiangdong, Ma, Chunhong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479760/
https://ncbi.nlm.nih.gov/pubmed/30862474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.02.007
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