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A Molecular Dynamics Approach to Explore the Intramolecular Signal Transduction of PPAR-α

Dynamics and functions of the peroxisome proliferator-activated receptor (PPAR)-α are modulated by the types of ligands that bind to the orthosteric sites. While several X-ray crystal structures of PPAR-α have been determined in their agonist-bound forms, detailed structural information in their apo...

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Pubblicato in:Int J Mol Sci
Autori principali: Basith, Shaherin, Manavalan, Balachandran, Shin, Tae Hwan, Lee, Gwang
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479491/
https://ncbi.nlm.nih.gov/pubmed/30987171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20071666
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