Design and synthesis of novel 5-(4-chlorophenyl)furan derivatives with inhibitory activity on tubulin polymerization

AIM: Discovery of novel series of colchicine binding site inhibitors (CBSIs). MATERIALS & METHODS: Isoxazoline 3a–d, pyrazoline 4a–b, 7a–f and 8a–f, cyclohexenone 9a–b and 10a–b or pyridine derivatives 11a–b were synthesized and evaluated for their inhibition of tubulin polymerization and cytoto...

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Detalhes bibliográficos
Publicado no:Future Med Chem
Main Authors: Moussa, Shaimaa A, A Osman, Essam Eldin, Eid, Nahed M, Abou-Seri, Sahar M, El Moghazy, Samir M
Formato: Artigo
Idioma:Inglês
Publicado em: Future Science Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479276/
https://ncbi.nlm.nih.gov/pubmed/29966433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fmc-2018-0036
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