The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence

Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet the Cryptococcus factors influencing patient outcome are not well understood. Pathogen-specific traits, such as the strain genotype and degree of antigen shedding, are associated with the clinical outcome, but the underlyin...

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Udgivet i:Infect Immun
Main Authors: Mukaremera, Liliane, McDonald, Tami R., Nielsen, Judith N., Molenaar, Christopher J., Akampurira, Andrew, Schutz, Charlotte, Taseera, Kabanda, Muzoora, Conrad, Meintjes, Graeme, Meya, David B., Boulware, David R., Nielsen, Kirsten
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Fungal and Parasitic Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479045/
https://ncbi.nlm.nih.gov/pubmed/30833336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00046-19
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