The Mouse Inhalation Model of Cryptococcus neoformans Infection Recapitulates Strain Virulence in Humans and Shows that Closely Related Strains Can Possess Differential Virulence

Cryptococcal meningitis (CM) causes high rates of HIV-related mortality, yet the Cryptococcus factors influencing patient outcome are not well understood. Pathogen-specific traits, such as the strain genotype and degree of antigen shedding, are associated with the clinical outcome, but the underlyin...

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Publicado en:Infect Immun
Autores principales: Mukaremera, Liliane, McDonald, Tami R., Nielsen, Judith N., Molenaar, Christopher J., Akampurira, Andrew, Schutz, Charlotte, Taseera, Kabanda, Muzoora, Conrad, Meintjes, Graeme, Meya, David B., Boulware, David R., Nielsen, Kirsten
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479045/
https://ncbi.nlm.nih.gov/pubmed/30833336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00046-19
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