Stable and Highly Immunogenic MicroRNA-Targeted Single-Dose Live Attenuated Vaccine Candidate against Tick-Borne Encephalitis Constructed Using Genetic Backbone of Langat Virus

Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is one of the most medically important tick-borne pathogens of the Old World. Despite decades of active research, attempts to develop of a live attenuated virus (LAV) vaccine against TBEV with acceptable safety and immunogenicit...

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Veröffentlicht in:mBio
Hauptverfasser: Tsetsarkin, Konstantin A., Maximova, Olga A., Liu, Guangping, Kenney, Heather, Teterina, Natalya L., Pletnev, Alexander G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6479010/
https://ncbi.nlm.nih.gov/pubmed/31015334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02904-18
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