Molecular subtyping reveals immune alterations associated with progression of bronchial premalignant lesions

Bronchial premalignant lesions (PMLs) are precursors of lung squamous cell carcinoma, but have variable outcome, and we lack tools to identify and treat PMLs at risk for progression to cancer. Here we report the identification of four molecular subtypes of PMLs with distinct differences in epithelia...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Beane, Jennifer E., Mazzilli, Sarah A., Campbell, Joshua D., Duclos, Grant, Krysan, Kostyantyn, Moy, Christopher, Perdomo, Catalina, Schaffer, Michael, Liu, Gang, Zhang, Sherry, Liu, Hanqiao, Vick, Jessica, Dhillon, Samjot S., Platero, Suso J., Dubinett, Steven M., Stevenson, Christopher, Reid, Mary E., Lenburg, Marc E., Spira, Avrum E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478943/
https://ncbi.nlm.nih.gov/pubmed/31015447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09834-2
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