The combination of neoantigen quality and T lymphocyte infiltrates identifies glioblastomas with the longest survival

Glioblastoma (GBM) is resistant to multimodality therapeutic approaches. A high burden of tumor-specific mutant peptides (neoantigens) correlates with better survival and response to immunotherapies in selected solid tumors but how neoantigens impact clinical outcome in GBM remains unclear. Here, we...

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Udgivet i:Commun Biol
Main Authors: Zhang, Jing, Caruso, Francesca P., Sa, Jason K., Justesen, Sune, Nam, Do-Hyun, Sims, Peter, Ceccarelli, Michele, Lasorella, Anna, Iavarone, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6478916/
https://ncbi.nlm.nih.gov/pubmed/31044160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0369-7
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